Endocrine Abstracts

Antiproliferative actions of 1,25(OH)2D3 (1,25D), the active form of Vitamin D, are reported in various types of cancer, whereas little is known about the underlying molecular mechanism. Interestingly, in non thyroid-cancer cells, stimulation with 1,25D has been shown to affect cell proliferation in a Sirtuin 1 (Sirt1) dependent manner. Sirtuin histon deacetylases are key factors in cell metabolism recently found to be overexpressed in different carcinoma...

Dysregulated T helper cells and vitamin D (VD) deficiency are important factors in the pathogenesis of Type 1 diabetes mellitus (T1D). Therefore, we investigated the immune effects of high dose VD-treatment on gene expression (GE) pattern in T helper cells (Th) before and after VD-therapy in patients with T1D.Methods: Seven T1D patients with 25(OH)D3 levels below 20 ng/ml received 3 months 4000 IU/d Vigantol oil. The 25(OH)D3 plasma...